Azithromycin
产品说明书
 |
同义名 : | 阿奇霉素 ;CP 62993; CP 62,993; Z-Pak |
| CAS号 : | 83905-01-5 | |
| 货号 : | A175409 | |
| 分子式 : | C38H72N2O12 | |
| 纯度 : | 98% | |
| 分子量 : | 748.98 | |
| MDL号 : | MFCD00873574 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Azithromycin, at a concentration of 2 µM, enhances rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from individuals with asthma. This effect is tied to the upregulation of RIG-I like receptors and suppression of viral replication. The knockdown of MDA5, but not RIG-I, reduces the azithromycin-enhanced viral-induced IFNβ expression in these cells[1]. Azithromycin also specifically lowers MMP-9 mRNA and protein levels without influencing NF-κB activity in endotoxin-challenged monocytic THP-1 cells[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03682653 | Childhood Mortality | Phase 4 | Not yet recruiting | February 2022 | - |
| NCT00865670 | Infection | Phase 1 | Completed | - | - |
| NCT02344628 | Yaws | Phase 3 | Completed | - | Ghana ... 展开 >> School Based Recruitment Ayensuanor District, Eastern Region, Ghana School Based Recruitment Upper West Akyem, Eastern Region, Ghana School Based Recruitment West Akyem District, Eastern Region, Ghana School Based Recruitment Nkwanta North District, Volta Region, Ghana Papua New Guinea Community Based Recruitment Karkar District, Madang Province, Papua New Guinea Community Based Recruitment Kavieng Subdistrict, New Ireland Province, Papua New Guinea United Kingdom London School of Hygiene and Tropical Medicine London, United Kingdom, WC1E 7HT 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.34mL 0.27mL 0.13mL |
6.68mL 1.34mL 0.67mL |
13.35mL 2.67mL 1.34mL |
| 参考文献 |
|---|