SYP-5
产品说明书
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同义名 : | - |
| CAS号 : | 1384268-04-5 | |
| 货号 : | A171766 | |
| 分子式 : | C18H16O3S | |
| 纯度 : | 98% | |
| 分子量 : | 312.38 | |
| MDL号 : | MFCD30534394 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SYP-5 acts as an inhibitor of the hypoxia-induced increase in HIF-1 levels. It effectively suppresses both HIF-1 and the subsequent gene expression in Hep3B and Bcap37 cells. SYP-5 also hinders the migration and invasion of tumor cells, along with tumor angiogenesis, by targeting the PI3K/AKT and MAPK/ERK pathways that are dependent on HIF-1. The HIF-1 target proteins, VEGF and MMP-2, are downregulated by SYP-5, which significantly curtails the hypoxia-driven overexpression of these proteins in both cell lines. In vitro, SYP-5 inhibits angiogenesis as observed in tube formation assays, induced by both hypoxia and VEGF. Moreover, SYP-5 slows down the migration and invasion of Hep3B and Bcap37 cells caused by hypoxia and FBS. Notably, SYP-5 selectively blocks the hypoxia-induced luciferase expression in U251-HRE cells but not in U251-pGL3[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.20mL 0.64mL 0.32mL |
16.01mL 3.20mL 1.60mL |
32.01mL 6.40mL 3.20mL |
| 参考文献 |
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