Oltipraz
产品说明书
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同义名 : | 吡噻硫酮 ;RP 35972; NSC 347901; CD1400 |
| CAS号 : | 64224-21-1 | |
| 货号 : | A169991 | |
| 分子式 : | C8H6N2S3 | |
| 纯度 : | 98% | |
| 分子量 : | 226.34 | |
| MDL号 : | MFCD00868499 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
IP 2% DMSO+2% Tween80+40% PEG300+water 2 mg/mL clear PO 0.5% CMC-Na 30 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Oltipraz is a potent chemopreventive agent which can inhibit the carcinogenicity of many environmental carcinogens in multiple target organs[6]. It is regarded as an activator of Nrf2. Treatment with Oltipraz led increased nuclear Nrf2 protein in liver sections from Oltipraz -treated mice. Also it led an induction of hepatic Mrp transporters through the Nrf2 transcriptional pathway[7]. Oltipraz coordinately increases multiple hepatic xenobiotic transporter mRNA levels. Sprague-Dawley rats treated with OPZ exhibited CAR-dependent increased mRNA and protein levels of both Nqo1 and Cyp2b1/2 by 24 h. But it induced microsomal epoxide hydrolase, NAD(P)H quinone oxidoreductase, and Cyp3a1/23, independent of CAR[8]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01393678 | Chronic Liver Disease | Phase 3 | Completed | - | Korea, Republic of ... 展开 >> Hanyang University Hospital Seoul, Seongdong-gu,, Korea, Republic of 收起 << |
| NCT00006457 | Lung Cancer | Phase 1 | Completed | - | United States, Illinois ... 展开 >> Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611-3013 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 收起 << |
| NCT01373554 | Non-alcoholic Fatty Liver Dise... 展开 >>ase 收起 << | Phase 2 | Completed | - | Korea, Republic of ... 展开 >> Inje University Ilsan Paik Hospital Dahwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706 NHUS Ilsan Hospital Ilsan-ro Ilsan-donggu, Goyang-si, Korea, Republic of, 410-719 Seoul National University Hospital Daehak-ro Jongno-gu, Seoul, Korea, Republic of, 110-744 Korea University Guro hospital Gurodong-ro, Seoul, Korea, Republic of, 152-703 Boramae Hospital Sindaebang-dong Dongjak-gu, Seoul, Korea, Republic of, 156-707 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.42mL 0.88mL 0.44mL |
22.09mL 4.42mL 2.21mL |
44.18mL 8.84mL 4.42mL |
| 参考文献 |
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