Astilbin
产品说明书
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同义名 : | Taxifolin 3-O-rhamnoside; Neoisoastilbin; Taxifolin 3-rhamnoside; Neoastilbin; Isoastilbin |
| CAS号 : | 29838-67-3 | |
| 货号 : | A169623 | |
| 分子式 : | C21H22O11 | |
| 纯度 : | 97% | |
| 分子量 : | 450.39 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Astilbin, a flavonoid compound, is isolated from the rhizome of Smilax glabra. Astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin could ameliorate the cisplatin-induced nephrotoxicity by reducing oxidative stress and inflammation[3]. In addition, kidney function parameters, including serum creatinine (Scr) and blood urea nitrogen (BUN) were restored in astilbin-treated hyperuricemic rats. Astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor κB (NLRP3/NF-κB), which is associated with the up-regulation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress[4]. Astilbin may be a promising agent for psoriasis treatment. Astilbin leads to S phase arrest of the cell cycle by induction of p53 and p21 and activated-AMPK. Moreover, astilbin regulates the expression of VEGF in human HaCaT keratinocytes[5]. The absolute bioavailability of astilbin was improved from 0.32 to 4.40% in rats through nanoparticle fabrication[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.22mL 0.44mL 0.22mL |
11.10mL 2.22mL 1.11mL |
22.20mL 4.44mL 2.22mL |
| 参考文献 |
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