Pamidronicacid

产品说明书

Print
Chemical Structure| 40391-99-9 同义名 : -
CAS号 : 40391-99-9
货号 : A169448
分子式 : C3H11NO7P2
纯度 : 98%+
分子量 : 235.07
MDL号 : MFCD00168777
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases. Osteosarcoma cell viability decreased significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 microM, most consistently after 48 and 72 hours' exposure[3]. Pamidronate disodium 1, 5, and 10 μg/ml were unfavorable for BMMSC growth (P < .05), whereas 0.1 and 0.5 μg/mL did not affect BMMSC growth (P ≥ .05). Pamidronate disodium 0.5 μg/mL decreased the expression of genes and proteins involved in Wnt and β-catenin signaling. Pamidronate disodium inhibited Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reversed the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs (bone marrow mesenchymal stem cells)[4]. PAM (Pamidronic Acid) can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration[5]. Intravenous APD (pamidronic acid) administration appears to be an effective and safe treatment of the severe hypercalcemia due to parathyroid carcinoma[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.25mL

0.85mL

0.43mL

21.27mL

4.25mL

2.13mL

42.54mL

8.51mL

4.25mL
参考文献

[1]Kubalek I, Fain O, et al. Treatment of reflex sympathetic dystrophy with pamidronate: 29 cases. Rheumatology (Oxford). 2001 Dec;40(12):1394-7.

[2]Ostenstad B, Andersen OK. Disodium pamidronate versus mithramycin in the management of tumour-associated hypercalcemia. Acta Oncol. 1992;31(8):861-4.

[3]Ashton JA, Farese JP, Milner RJ, Lee-Ambrose LM, van Gilder JM. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs. Am J Vet Res. 2005 May;66(5):885-91

[4]Xu Y, Sun J, Yang X, Yu Y, Mai H, Li Z. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Oct;75(10):2135-2143

[5]Lv Y, Xia JY, Chen JY, Zhao H, Yan HC, Yang HS, Li Q, Fan YX, Guo KJ, Chen XY. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370

[6]Vega EM, Mautalen CA. Intravenous pamidronic acid in hypercalcemia due to parathyroid carcinoma. Medicina (B Aires). 1991;51(2):106-10