KGP94

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Chemical Structure| 1131456-28-4 同义名 : -
CAS号 : 1131456-28-4
货号 : A1678570
分子式 : C14H12BrN3OS
纯度 : 99%+
分子量 : 350.23
MDL号 : N/A
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 KGP94 is a selective cathepsin L inhibitor with an IC50 value of 189 nM[1].KGP94 inhibits migration and invasion of metastatic cancers and shows low cytotoxicity against a variety of human cell lines (GI50=26.9 µM)[2].At concentrations of 10 µM or 20 µM, acting for 24 hours, KGP94 reduces the expression of markers of macrophage M2 (arginase-1 and CD206) as well as cellular invasion by primary bone marrow-derived macrophages or Raw264.7[3].At a concentration of 25 μM for 24 hours of treatment, the effects of KGP94 on the invasive capacity of prostate and respiratory cancer cells were 53% and 88%, respectively, and the inhibition of CTSL activity secreted by PC-3ML and MDA-MB-231 was 94% and 92%, respectively[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.28mL

2.86mL

1.43mL

28.55mL

5.71mL

2.86mL