Lirafugratinib HCl

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Chemical Structure| 2688040-45-9 同义名 : RLY-4008 hydrochloride
CAS号 : 2688040-45-9
货号 : A1678567
分子式 : C28H25ClFN7O2
纯度 : 99%+
分子量 : 546.0
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Lirafugratinib (RLY-4008) hydrochloride is an orally active, irreversible, and highly selective FGFR2 inhibitor with an IC50 of 3 nM. It covalently binds to Cys491 and targets FGFR2 primary alterations and resistance mutations, inducing tumor regression while sparing other FGFRs[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.16mL

1.83mL

0.92mL

18.32mL

3.66mL

1.83mL
参考文献

[1]Vivek Subbiah, et al. RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov. 2023 Sep 6;13(9):2012-2031.