Zasocitinib

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Chemical Structure| 2272904-53-5 同义名 : Ndi-034858; TAK-279
CAS号 : 2272904-53-5
货号 : A1677663
分子式 : C23H24N8O3
纯度 : 99%+
分子量 : 460.49
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Zasocitinib (NDI-034858) is an inhibitor of TYK2, targeting the TYK2 JH2 domain with a binding constant Kd of <200 pM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.86mL

2.17mL

1.09mL

21.72mL

4.34mL

2.17mL
参考文献

[1]Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.

[2]Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.