SARS-CoV-2-IN-13

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Chemical Structure| 56961-10-5 同义名 : -
CAS号 : 56961-10-5
货号 : A1671728
分子式 : C13H8Cl2N2O4
纯度 : 99%
分子量 : 327.12
MDL号 : MFCD34676438
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SARS-CoV-2-IN-13, a potent SARS-CoV-2 inhibitor with an IC50 of 0.057 μM, is a niclosamide analogue. This compound demonstrates enhanced stability in human plasma and liver S9 enzymes assays compared to niclosamide, potentially offering better bioavailability and an extended half-life when taken orally[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.57mL

6.11mL

3.06mL
参考文献

[1]Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.