Exarafenib

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Chemical Structure| 2639957-39-2 同义名 : RAF/KIN_2787; KIN-002787; Exarafenib, RAF/KIN_2787; KIN-2787
CAS号 : 2639957-39-2
货号 : A1671177
分子式 : C26H34F3N5O3
纯度 : 99%+
分子量 : 521.58
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Exarafenib (RAF/KIN_2787) is an oral, selective pan-RAF inhibitor effective against RAF-dependent cancers, covering all types of BRAF mutations. It inhibits MAPK signaling in RAF-dependent melanoma cell lines and exhibits anticancer properties[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.59mL

1.92mL

0.96mL

19.17mL

3.83mL

1.92mL
参考文献

[1]Miller N, et, al. Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma.2022 Jun 2;40(16): e15099.

[2]WHO Drug Information. International Nonproprietary Names for Pharmaceutical