Tiotropium Bromide
产品说明书
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同义名 : | BA679 BR; Tiotropium (bromide) |
| CAS号 : | 136310-93-5 | |
| 货号 : | A166270 | |
| 分子式 : | C19H22BrNO4S2 | |
| 纯度 : | 98% | |
| 分子量 : | 472.42 | |
| MDL号 : | MFCD00867027 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tiotropium bromide, a new long-lasting anticholinergic drug, binds with high affinity to muscarinic receptors but dissociates very slowly from M(1)- and M(3)-muscarinic receptors. Tiotropium bromide will become the most widely used bronchodilator for COPD (chronic obstructive pulmonary disease) patients in the future[3]. Moreover, Tiotropium inhalation attenuates RB-induced (Resistive breathing) pulmonary inflammation[4]. Tiotropium bromide at >15 pg/mL inhibited IL-8 production from both BEAS-2B cells and LFs (lung fibroblasts) after LPS stimulation, and thus may contribute to lower cellular inflammation in COPD[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01257230 | Asthma | Phase 3 | Completed | - | - |
| NCT02039011 | Asthma | Phase 4 | Completed | - | United Kingdom ... 展开 >> Asthma and Allergy Research Group, University of Dundee Dundee, United Kingdom, DD1 3AU 收起 << |
| NCT00949975 | Chronic Obstructive Pulmonary ... 展开 >>Disease 收起 << | Phase 2 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.12mL 0.42mL 0.21mL |
10.58mL 2.12mL 1.06mL |
21.17mL 4.23mL 2.12mL |
| 参考文献 |
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