NQDI-1

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Chemical Structure| 175026-96-7 同义名 : -
CAS号 : 175026-96-7
货号 : A165916
分子式 : C19H13NO4
纯度 : 98%+
分子量 : 319.31
MDL号 : MFCD03265970
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

5%dmso+40%PEG300+5%tween-80+water 0.5 mg/mL

生物活性
靶点

  • ASK1

    ASK1, IC50:3 μM

  • ASK1

    ASK1, IC50:3 μM

  • ASK1

    ASK1, IC50:3 μM
描述 NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.13mL

0.63mL

0.31mL

15.66mL

3.13mL

1.57mL

31.32mL

6.26mL

3.13mL
参考文献

[1]Hao H, Li S, et al. NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death. Mol Med Rep. 2016 Jun;13(6):4585-92.

[2]Eaton GJ, Zhang QS, et al.Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival. Cell Death Dis. 2014 Nov 13;5:e1522.