IDO5L

产品说明书

Print
Chemical Structure| 914471-09-3 同义名 : INCB024360 analog; Epacadostat analogue; INCB14943
CAS号 : 914471-09-3
货号 : A165598
分子式 : C9H7ClFN5O2
纯度 : 99%
分子量 : 271.64
MDL号 : -
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 5 mg/mL clear

PO 0.5% CMC-Na 30 mg/mL suspension

生物活性
描述 IDO5L is a potent inhibitor of IDO with an IC50 value of 19 nM in Hela cells[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
HEK293 clone 6 cells Function assay Inhibition of human IDO1 transfected in HEK293 clone 6 cells by HPLC analysis 22616902
human HeLa cells Function assay Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometry, IC50=19 nM 19507862
mouse B16 cells Function assay Inhibition of indoleamine 2,3-dioxygenase in mouse B16 cells assessed as kynurenine formation by spectrophotometry, IC50=46 nM 19507862
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.68mL

0.74mL

0.37mL

18.41mL

3.68mL

1.84mL

36.81mL

7.36mL

3.68mL
参考文献

[1]Yue EW, et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52(23):7364-7.