同义名 :	GSK180736
	CAS号 :	817194-38-0
	货号 :	A164666
	分子式 :	C19H16FN5O2
	纯度 :	99%+
	分子量 :	365.36
	MDL号 :	MFCD30533616
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	GSK180736A emerges as a potent inhibitor of Rho-associated coiled-coil kinase 1 (ROCK1), exhibiting an IC50 value of 100 nM. Its action extends as a selective and ATP-competitive inhibitor of G protein-coupled receptor kinase 2 (GRK2), with an IC50 of 0.77 μM[1].

细胞研究
细胞系	浓度	检测类型	检测时间	活性说明	数据源
Sf9 cells		Function assay		Inhibition of human recombinant ROCK1 kinase expressed in insect Sf9 cells by SPA, IC50=0.014 μM	18842034
Sf9 cells	10 mM	Function assay		Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM, IC50=0.014 μM	17201405

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.74mL 0.55mL 0.27mL	13.69mL 2.74mL 1.37mL	27.37mL 5.47mL 2.74mL

参考文献
[1]Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016 Apr 28;59(8):3793-807.