同义名 :	BAY-1895344; BAY 1895344
	CAS号 :	1876467-74-1
	货号 :	A164508
	分子式 :	C20H21N7O
	纯度 :	99%+
	分子量 :	375.43
	MDL号 :	MFCD31561442
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Elimusertib, also known as BAY-1895344, is an effective, orally active, selective ATR inhibitor with an IC50 of 7 nM. It exhibits antitumor activity[1][2]. Elimusertib effectively inhibits the proliferation of various human tumor cell lines, with a median IC50 value of 78 nM. Elimusertib also effectively inhibits hydroxyurea-induced H2AX phosphorylation (IC50: 36 nM)[1]. Elimusertib exhibits effective anti-proliferative activity in vitro against various cancer cell lines, such as in the CRC cell lines HT-29 (IC50: 160 nM) and LoVo (IC50: 71 nM), as well as in the B-cell lymphoma cell line SU-DHL-8 (IC50: 9 nM)[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.66mL 0.53mL 0.27mL	13.32mL 2.66mL 1.33mL	26.64mL 5.33mL 2.66mL

参考文献
[1]Wengner AM, Siemeister G, Lücking U, et al. The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer models. Mol Cancer Ther. 2019