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Chemical Structure| 176199-48-7 同义名 : LY354740; Eglumetad
CAS号 : 176199-48-7
货号 : A163426
分子式 : C8H11NO4
纯度 : 98%
分子量 : 185.18
MDL号 : MFCD04113018
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 LY354740 is a group II (mGlu2/3) metabotropic glutamate receptor agonist. It potently activates mGlu2 and mGlu3 with EC50 values of 5 and 24 nM, respectively[3]. LY354740 at a dose of 15 or 30mg/kg reduced spontaneous locomotor activity in wild‐type and Gria1-/- mice[4]. The i.p. administration of LY354740 decreased the number of mice exhibiting limbic seizures in this model with an EC50 value of 17mg/kg[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.40mL

1.08mL

0.54mL

27.00mL

5.40mL

2.70mL

54.00mL

10.80mL

5.40mL
参考文献

[1]Boerner T, Bygrave AM, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912-921.

[2]Orlando R, Borro M, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 Nov;86:133-44.

[3]Metabotropic Glutamate Receptors

[4]Boerner T, Bygrave AM, Chen J, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017;45(7):912-921. doi:10.1111/ejn.13539

[5]Monn JA, Valli MJ, Massey SM, et al. Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem. 1997;40(4):528-537. doi:10.1021/jm9606756