Liarozole
产品说明书
 |
同义名 : | R75251 |
| CAS号 : | 115575-11-6 | |
| 货号 : | A161291 | |
| 分子式 : | C17H13ClN4 | |
| 纯度 : | 98%+ | |
| 分子量 : | 308.76 | |
| MDL号 : | MFCD00864664 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Liarozole is an imidazole derivative and metabolic blocker of retinoic acid with oral activity. Liarozole inhibits CYP26-dependent 4-hydroxylation of retinoic acid with an IC50 value of 7 μM, leading to an increase in tissue levels of retinoic acid. Liarozole possesses antitumour properties[1][2][3].In MCF-7 cells, Liarozole inhibits cell proliferation at concentrations ranging from 0.01-10 μM for 9 days of treatment[3].In mesenchymal cells, Liarozole completely inhibited chondrogenesis at a concentration of 1 μM for 4 days of treatment[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.24mL 0.65mL 0.32mL |
16.19mL 3.24mL 1.62mL |
32.39mL 6.48mL 3.24mL |
