同义名 :	-
	CAS号 :	55482-89-8
	货号 :	A158767
	分子式 :	C16H14O5
	纯度 :	95%
	分子量 :	286.28
	MDL号 :	MFCD00864354
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Guacetisal (Broncaspin). a new active principle, obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis. Guacetisal was generally well tolerated. It has considerable therapeutic effectiveness and produced early, lasting reduction in temperature, heart frequency, dyspnoea, duration of expirium and in the intensity and number of coughing attacks. Guacetisal exerts its polyvalent activity to a proportionately higher extent in the bronchial districts more seriously involved in the inflammatory process, inducing an elective improvement in bronchial permeability, a reduction in total pulmonary resistances--with consequent tendency for ventilation-perfusion relations to normalise--as well as an improvement in gas exchanges and patient oxygenation[3]. Guacetisal was administered to a group of patients suffering from chronic asthmatic bronchitis. The drug in question was shown to possess a good fluidifying, expectorant and indirect anti-cough action, by means of an initial increase of the bronchial secretions and a subsequent progressive decrease of secretions towards the end of the treatment[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.49mL 0.70mL 0.35mL	17.47mL 3.49mL 1.75mL	34.93mL 6.99mL 3.49mL

参考文献

[1]Vizioli A, Zamperini D, Ursaia G. [Clinical trial of guacetisal in aged subjects with inflammatory diseases of the respiratory tract] . Clin Ter. 1982 Dec 15;103(5):527-33. Italian. [2]Galzigna L, Licit L, et al. Synthesis and some properties of two salsalate derivatives. Farmaco. 1993 Jan;48(1):95-103. [3]Caltagirone S, Vagliasindi M, Palermo F, Di Maria GU, Crimi N, Cusmano F. Studio clinico controllato sul trattamento della bronchite cronica con guacetisal [Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. Minerva Med. 1981 Feb 28;72(7):339-46. Italian [4]Bande G, Coghe M, Meloni M, Nonne G. Rilievi clinico-funzionali in bronchitici cronici asmatici trattati con guacetisal [Clinico-functional data concerning chronic asthmatic bronchitis patients treated wih guacetisal]. Minerva Med. 1981 Feb 28;72(7):321-4. Italian