Pipecolic acid

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Chemical Structure| 535-75-1 同义名 : DL-哌啶甲酸;六氢吡啶-alpha-羧酸;2-哌啶甲酸;哌啶-2-羧酸;呢可酸 ;piperidine-2-carboxylic acid
CAS号 : 535-75-1
货号 : A158487
分子式 : C6H11NO2
纯度 : 98%
分子量 : 129.16
MDL号 : MFCD00064347
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites[1]. Pipecolic acid, a non-proteinogenic amino acid, is a metabolite in lysine metabolism and a key chiral precursor in local anesthesia and macrolide antibiotics[2]. Pipecolic acid (Pip) is an essential component of systemic acquired resistance, priming resistance in Arabidopsis thaliana against (hemi)biotrophic pathogens. Exogenous application of Pip induced resistance in barley against the hemibiotrophic bacterial pathogen Xanthomonas translucens pv. cerealis. Pip induces barley innate immune responses by triggering NO and priming reactive oxygen species accumulation[3]. Moreover, in plants, Pip confers SAR by increasing levels of the free radicals, nitric oxide (NO), and reactive oxygen species (ROS), which act upstream of glycerol-3-phosphate (G3P)[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.74mL

1.55mL

0.77mL

38.71mL

7.74mL

3.87mL

77.42mL

15.48mL

7.74mL

参考文献

[1]He M. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7

[2]Han YH, Choi TR, Park YL, Park JY, Song HS, Kim HJ, Lee SM, Park SL, Lee HS, Bhatia SK, Gurav R, Yang YH. Enhancement of pipecolic acid production by the expression of multiple lysine cyclodeaminase in the Escherichia coli whole-cell system. Enzyme Microb Technol. 2020 Oct;140:109643

[3]Lenk M, Wenig M, Bauer K, Hug F, Knappe C, Lange B, Timsy, Häußler F, Mengel F, Dey S, Schäffner A, Vlot AC. Pipecolic Acid Is Induced in Barley upon Infection and Triggers Immune Responses Associated with Elevated Nitric Oxide Accumulation. Mol Plant Microbe Interact. 2019 Oct;32(10):1303-1313

[4]Wang C, Liu R, Lim GH, de Lorenzo L, Yu K, Zhang K, Hunt AG, Kachroo A, Kachroo P. Pipecolic acid confers systemic immunity by regulating free radicals. Sci Adv. 2018 May 30;4(5):eaar4509