Ruxolitinib phosphate
产品说明书
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同义名 : | 磷酸鲁索利替尼 ;INCB018424 phosphate; Ruxolitinib (phosphate); INCB 018424 (phosphate); INC 424 (phosphate); INC424; INCB018424 |
| CAS号 : | 1092939-17-7 | |
| 货号 : | A157761 | |
| 分子式 : | C17H21N6O4P | |
| 纯度 : | 98% | |
| 分子量 : | 404.36 | |
| MDL号 : | MFCD18452860 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ruxolitinib (INCB018424) specifically and potently inhibits signaling and proliferation mediated by JAK2V617F. It inhibits the growth of HEL cells with an EC50 of 186 nM, significantly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell systems, and inhibits proliferation of hematopoietic progenitor cells from primary MPN patient samples[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03616184 | Graft-versus-host-disease (GVH... 展开 >>D) 收起 << | Phase 2 | Recruiting | April 2024 | United States, Nebraska ... 展开 >> University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Penny Nurse Coordinator, RN 402-559-4596 收起 << |
| NCT03386214 | Myelofibroses | Phase 1 | Recruiting | March 31, 2021 | United States, Missouri ... 展开 >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Stephen Oh, M.D., Ph.D. 314-747-7960 stoh@wustl.edu Principal Investigator: Stephen Oh, M.D., Ph.D. Sub-Investigator: Amy Zhou, M.D. 收起 << |
| NCT00674479 | Acute Myeloid Leukemia ... 展开 >> Acute Lymphocytic Leukemia Myelodysplastic Syndrome Chronic Myelogenous Leukemia 收起 << | Phase 2 | Completed | - | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.47mL 0.49mL 0.25mL |
12.37mL 2.47mL 1.24mL |
24.73mL 4.95mL 2.47mL |
| 参考文献 |
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