Cryptotanshinone

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Chemical Structure| 35825-57-1 同义名 : 隐丹参醌 ;Cryptotanshinon; Tanshinone c
CAS号 : 35825-57-1
货号 : A157592
分子式 : C19H20O3
纯度 : 98%
分子量 : 296.36
MDL号 : -
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

5% DMSO+40%PEG 300+5% Tween80 +water 1.25 mg/mL

生物活性
靶点

  • STAT3

    STAT3, IC50:4.6 μM

  • STAT3

    STAT3, IC50:4.6 μM

  • STAT3

    STAT3, IC50:4.6 μM
描述 Cryptotanshinone, a compound derived from the root of Salvia miltiorrhiza Bunge, exhibits antitumor properties. It inhibits STAT3 with an IC50 of 4.6 μM.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
human AGS cells Function assay 16 h Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay, IC50=1.58 μM 17583950
human AGS cells Growth inhibition assay 24 h Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay, IC50=10.2 μM 17583950
human HCT116 cells Function assay 24 h Inhibition of STAT3 expressed in human HCT116 cells after 24 hrs by luciferase reporter gene assay, ic50=4.6 μM 22650325
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.74mL

6.75mL

3.37mL
参考文献

[1]Shin DS, Kim HN, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1;69(1):193-202.

[2]Kim EJ, Jung SN, et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol Pharmacol. 2007 Jul;72(1):62-72.

[3]Song M, Hang TJ, et al. Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur J Pharm Sci. 2007 Dec;32(4-5):247-53. Epub 2007 Aug 15.

[4]Pan Y, Bi HC, et al. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica. 2008 Apr;38(4):382-98.