ONO-8430506

产品说明书

Print
Chemical Structure| 1354805-08-5 同义名 : -
CAS号 : 1354805-08-5
货号 : A1554598
分子式 : C27H28FN3O3
纯度 : 98%
分子量 : 461.53
MDL号 : MFCD34604003
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ONO-8430506 is an orally bioavailable and potent inhibitor of autotaxin (ATX)/ENPP2, displaying an IC90 of 100 nM for inhibiting ATX activity in mouse plasma[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL
参考文献

[1]Matthew G K Benesch, et al. Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. FASEB J. 2014 Jun;28(6):2655-66.

[2]Hiroshi Saga, et al. A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension. PLoS One. 2014 Apr 18;9(4):e93230.

[3]Yuzo Iwaki, et al. ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model. ACS Med Chem Lett. 2020 May 14;11(6):1335-1341.