FCPR03
产品说明书
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同义名 : | - |
| CAS号 : | 1917347-65-9 | |
| 货号 : | A1550465 | |
| 分子式 : | C15H19F2NO3 | |
| 纯度 : | 99% | |
| 分子量 : | 299.31 | |
| MDL号 : | MFCD34469276 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | FCPR03 is a potent and selective PDE4 inhibitor with IC50 values of 60 nM for the PDE4 catalytic domain, 31 nM for PDE4B1, and 47 nM for PDE4D7. FCPR03 is at least 2100-fold more selective than other PDEs (PDE1-3 and PDE5-11). FCPR03 has anti-inflammatory, neuroprotective and antidepressant-like effects[1][2].FCPR03 increases HT-22 cell viability in a dose-dependent manner at concentrations of 5-20 μM for 30 h. FCPR03 at 10 μM has a significant protective effect[1][2].At a concentration of 20 μM, FCPR03 protected HT-22 cells and cortical neurons from OGD-induced apoptosis. FCPR03 also restored the levels of mitochondrial membrane potential (MMP) and ROS. FCPR03 increased the levels of phosphorylated AKT, GSK3β, and β-catenin in HT-22 cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.34mL 0.67mL 0.33mL |
16.71mL 3.34mL 1.67mL |
33.41mL 6.68mL 3.34mL |
