Valategrast HCl

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Chemical Structure| 828271-96-1 同义名 : R-411; Valategrast hydrochloride; RO27244; RO-27-2441; RO-0272441
CAS号 : 828271-96-1
货号 : A1550416
分子式 : C30H33Cl4N3O4
纯度 : 98%+
分子量 : 641.41
MDL号 : MFCD18782680
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Valategrast hydrochloride (R-411) serves as a strong antagonist of both integrin α4β1 (VLA-4) and α4β7. It has potential applications in the treatment of Chronic Obstructive Pulmonary Disease (COPD) and asthma[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.56mL

0.31mL

0.16mL

7.80mL

1.56mL

0.78mL

15.59mL

3.12mL

1.56mL
参考文献

[1]Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.

[2]Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.