Acoramidis HCl
产品说明书
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同义名 : | AG10 hydrochloride; Acoramidis hydrochloride |
| CAS号 : | 2242751-53-5 | |
| 货号 : | A1544116 | |
| 分子式 : | C15H18ClFN2O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 328.77 | |
| MDL号 : | MFCD33023202 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Acoramidis HCl is an orally active, selective kinetic stabiliser of wild-type and V122I mutant TTR (transthyretin).Acoramidis HCl is used in the study of transthyretin amyloidosis[1][2].Acoramidis HCl stabilises V122I-TTR and WT-TTR reasonably well at concentrations of 0.1-10 µM (TTR ∼5 µM), and is also effective in stabilising wild-type and mutant TTRs in whole serum[1].Acoramidis HCl stimulates mitochondrial QO2 in a concentration-dependent manner at concentrations ranging from 10 to 100 µM[3].Acoramidis HCl showed minimal inhibition of two common non-targets in drug discovery, the potassium channel hERG (IC50 > 100 µM) and multiple cytochrome P450 isozymes (IC50 > 50 µM) (low toxicity)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.04mL 0.61mL 0.30mL |
15.21mL 3.04mL 1.52mL |
30.42mL 6.08mL 3.04mL |
