Chrysotoxine

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Chemical Structure| 156951-82-5 同义名 : -
CAS号 : 156951-82-5
货号 : A1539742
分子式 : C18H22O5
纯度 : 98%+
分子量 : 318.36
MDL号 : MFCD22200427
存储条件:

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Chrysotoxine inhibits both Src and Akt. It decreases the characteristics of cancer stem cells (CSCs) by lowering Src/Akt signaling. Chrysotoxine decreases cell viability and boosts apoptosis in H460 and H23 cells, but not in non-tumor cell lines. It exhibits quick excretion and limited bioavailability in rats. Chrysotoxine is employed in cancer[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL

参考文献

[1]Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346.

[2]Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.