BMS-986235

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Chemical Structure| 2253947-47-4 同义名 : LAR-1219
CAS号 : 2253947-47-4
货号 : A1538642
分子式 : C18H17F2N3O3
纯度 : 99%+
分子量 : 361.34
MDL号 : MFCD32874122
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BMS-986235 (LAR-1219) is an orally active, selective agonist of formyl peptide receptor 2 (FPR2), with EC50 values of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 demonstrates promise for heart failure prevention[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL
参考文献

[1]Asahina Y, et al. Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure [published online ahead of print, 2020 May 24]. J Med Chem. 2020;10.1021/acs.jmedchem.9b02101.