PF-00835231

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Chemical Structure| 870153-29-0 同义名 : -
CAS号 : 870153-29-0
货号 : A1534055
分子式 : C24H32N4O6
纯度 : 95%
分子量 : 472.53
MDL号 : MFCD33029312
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PF-00835231 is an inhibitor of the CoV-2 cysteine 3C-like protease (3CLpro), exhibiting IC50 values of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively. PF-00835231 has been developed for research purposes in the context of anti-SARS-CoV-2/COVID-19 [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.58mL

2.12mL

1.06mL

21.16mL

4.23mL

2.12mL
参考文献

[1]Robert L Hoffman, et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725-12747.