AZ194

产品说明书

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Chemical Structure| 2241651-99-8 同义名 : -
CAS号 : 2241651-99-8
货号 : A1533464
分子式 : C34H31F2N3O3
纯度 : 95%
分子量 : 567.63
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 AZ194 is a pioneering, orally administered inhibitor that disrupts the CRMP2-Ubc9 interaction and inhibits NaV1.7 with an IC50 of 1.2 µM. It prevents the SUMOylation of CRMP2, effectively decreasing the amount of NaV1.7 expressed on the cell surface and provides antinociceptive effects[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.81mL

1.76mL

0.88mL

17.62mL

3.52mL

1.76mL
参考文献

[1]Cai S, et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Sci Transl Med. 2021;13(619):eabh1314.