GNE-9815

产品说明书

Print
Chemical Structure| 2729996-45-4 同义名 : -
CAS号 : 2729996-45-4
货号 : A1530789
分子式 : C26H22FN5O2
纯度 : 98%
分子量 : 455.48
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 GNE-9815 is a potent, highly selective, pan-RAF inhibitor with excellent oral bioavailability. It shows Ki values of 0.062 nM for CRAF and 0.19 nM for BRAF. GNE-9815, in combination with the MEK inhibitor Cobimetinib, effectively modulates the MAPK pathway, making it suitable for research on KRAS mutant cancers[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

10.98mL

2.20mL

1.10mL

21.95mL

4.39mL

2.20mL
参考文献

[1]Huestis MP, et al. Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor. ACS Med Chem Lett. 2021 Apr 21;12(5):791-797.