同义名 :	-
	CAS号 :	380315-80-0
	货号 :	A152615
	分子式 :	C20H23N3O2S
	纯度 :	98%
	分子量 :	369.48
	MDL号 :	MFCD02914760
	存储条件：	Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Tenovin-1, functioning as a p53 activator, shields p53 from degradation facilitated by MDM2. Its mechanism involves the inhibition of protein deacetylating activities of SirT1 and SirT2. Additionally, Tenovin-1 serves as an inhibitor of dihydroorotate dehydrogenase (DHODH)[1][2].

细胞研究
细胞系	浓度	检测类型	检测时间	活性说明	数据源
MCF7 cells	10 μM	Function assay	6 h	Inhibition of SirT1 assessed as increase in p53 expression in human MCF7 cells at 10 uM after 6 hrs by Western blotting	22304848

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.71mL 0.54mL 0.27mL	13.53mL 2.71mL 1.35mL	27.07mL 5.41mL 2.71mL

参考文献

[1]Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008;13(5):454-463. [2]Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. [3]Marx C, et al. The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs. 2017 Nov 18. [4]Yoon KB, et al. Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. Immune Netw. 2016 Jun;16(3):183-8. [5]Grbesa I, et al. Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. PLoS One. 2015 Apr 27;10(4):e0124670.