DAPT
产品说明书
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同义名 : | GSI-IX; LY-374973; N-(2FPhAc)Ala-phenyl-Gly t-butyl ester.; DAPT peptide |
| CAS号 : | 208255-80-5 | |
| 货号 : | A150458 | |
| 分子式 : | C23H26F2N2O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 432.46 | |
| MDL号 : | MFCD04974585 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
IP 2% DMSO+2% Tween80+40% PEG300+water 5 mg/mL clear PO 0.5% CMC-Na 27 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | DAPT (GSI-IX), a powerful and orally bioavailable γ-secretase inhibitor, exhibits IC50 values of 115 nM for total amyloid-β (Aβ) and 200 nM for Aβ42. It blocks Notch 1 signaling activation and promotes cell differentiation. Additionally, DAPT triggers autophagy and apoptosis, offers neuroprotective effects, and holds therapeutic potential for autoimmune, lymphoproliferative disorders, degenerative diseases, and cancer[1][2]. DAPT (GSI-IX) (GMP) refers to DAPT manufactured according to GMP standards. GMP-compliant small molecules function effectively as supporting agents in the production of cell therapies. DAPT acts as a potent, orally administrable γ-secretase inhibitor[1][2]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| A549 | 10 μM | Growth Inhibition Assay | 24h | decreases the cell viability combined with PTE | 23671619 |
| A549 CD133− | 2 μM | Growth Inhibition Assay | 48 h | enhances cell growth inhibition induced by CDDP | 24502949 |
| A549 CD133+ | 2 μM | Growth Inhibition Assay | 48 h | enhances cell growth inhibition induced by CDDP | 24502949 |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.31mL 0.46mL 0.23mL |
11.56mL 2.31mL 1.16mL |
23.12mL 4.62mL 2.31mL |
| 参考文献 |
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