同义名 :	-
	CAS号 :	447415-26-1
	货号 :	A1500053
	分子式 :	C28H27NO6
	纯度 :	98%
	分子量 :	473.52
	MDL号 :	MFCD34474078
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. It is derived from the selective thyromimetic GC-1 and inhibits the binding of thyroid hormones to their receptor as well as cofactor recruitment[1][2][3]. NH-3 serves as a click chemistry reagent, containing an Alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.11mL 0.42mL 0.21mL	10.56mL 2.11mL 1.06mL	21.12mL 4.22mL 2.11mL

参考文献

[1]Latika Singh, et al. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81(5):1870-6. [2]Gary J Grover, et al. Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther. 2007 Jul;322(1):385-90. [3]Wayland Lim, et al. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem. 2002 Sep 20;277(38):35664-70.