JTE-607
产品说明书
 |
同义名 : | JTE 607二盐酸盐 ;JTE-607 Dihydrochloride |
| CAS号 : | 188791-09-5 | |
| 货号 : | A1493432 | |
| 分子式 : | C25H33Cl4N3O5 | |
| 纯度 : | 98% | |
| 分子量 : | 597.36 | |
| MDL号 : | MFCD07363998 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | JTE-607 is a highly selective inhibitor of inflammatory cytokine synthesis that protects mice from endotoxic shock. JTE-607 inhibits LPS-stimulated inflammatory cytokines produced by human PBMC, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, with IC50 values of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively, and the mRNA expression of these cytokines was also inhibited by JTE-607[1].JTE607 inhibits LPS-stimulated IL-8 production by monkey and rabbit PBMC, and TNF-α production by mouse and rat PBMC with IC50 values of 59, 780, 1600, and 19000 nM, respectively. JTE-607 can also inhibit other cytokines, granulocyte-macrophage colony-stimulating factor and IL-1RA, with IC50 of 2.4±0.8 and 5.4±0.4 nM respectively[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.67mL 0.33mL 0.17mL |
8.37mL 1.67mL 0.84mL |
16.74mL 3.35mL 1.67mL |
