ALE-0540

产品说明书

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Chemical Structure| 234779-34-1 同义名 : -
CAS号 : 234779-34-1
货号 : A1483462
分子式 : C14H11N3O5
纯度 : 98%+
分子量 : 301.25
MDL号 : N/A
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ALE-0540, a nonpeptidic small molecule, acts as a nerve growth factor receptor antagonist. It disrupts NGF binding to tyrosine kinase (Trk) A, or to both p75 and TrkA, with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 is valuable in studying mechanisms underlying pain treatment development [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.32mL

0.66mL

0.33mL

16.60mL

3.32mL

1.66mL

33.20mL

6.64mL

3.32mL
参考文献

[1]Owolabi JB, et al. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6.