RNF5 inhibitor inh-02

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Chemical Structure| 324579-65-9 同义名 : -
CAS号 : 324579-65-9
货号 : A1483372
分子式 : C23H20N4S
纯度 : 98%
分子量 : 384.5
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 The RNF5 inhibitor inh-02 effectively inhibits the E3 ubiquitin ligase RNF5/RMA1. It results in substantial rescue of F508del-CFTR (EC50=2.2 μM) in bronchial epithelial cells carrying the F508del mutation. This inhibitor holds promise for cystic fibrosis research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8.