2,2',4,4'-Tetrabromodiphenyl Ether
产品说明书
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同义名 : | BDE 47 |
| CAS号 : | 5436-43-1 | |
| 货号 : | A148194 | |
| 分子式 : | C12H6Br4O | |
| 纯度 : | 95% | |
| 分子量 : | 485.79 | |
| MDL号 : | MFCD00626457 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is the predominant congener of polybrominated diphenyl ethers (PBDEs) detected in human serum. BDE-47 could induce neurotransmitter system disturbance, abnormal phosphorylation, mitochondrial dysfunction and oxidative stress[3]. Zebrafish embryos at 4 h post-fertilization (hpf) were exposed to 0.312, 0.625 and 1.25 mg/L BDE-47 to 74-120 hpf. BDE-47 instigated a dose-related developmental toxicity, evidenced by reduced embryonic survival and hatching rate, shortened body length and increased aberration rate. Meanwhile, higher doses of BDE-47 reduced mitochondrial membrane potential and ATP production but increased apoptosis in zebrafish embryos. Moreover, exposure to BDE-47 at 0.625 or 1.25 mg/L impaired mitochondrial biogenesis and mitochondrial dynamics[4]. The cell divisions of T. pseudonana were severely inhibited by the stress of BDE-47, but the photosynthetic parameters were much less declined and recovered earlier than the cell divisions in the same BDE-47 treatments[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.06mL 0.41mL 0.21mL |
10.29mL 2.06mL 1.03mL |
20.59mL 4.12mL 2.06mL |
| 参考文献 |
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