Latrepirdine 2HCl

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Chemical Structure| 97657-92-6 同义名 : Dimebolin dihydrochloride; Dimebolin (hydrochloride); Latrepirdine; Dimebon; Latrepirdine dihydrochloride
CAS号 : 97657-92-6
货号 : A148043
分子式 : C21H27Cl2N3
纯度 : 99%
分子量 : 392.37
MDL号 : MFCD01617545
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • 5-HT

  • 5-HT

  • Histamine receptor

  • Histamine receptor
描述 Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.49mL

5.10mL

2.55mL
参考文献

[1]Steele JW, Lachenmayer ML, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug;18(8):889-97.

[2]Zhang S, Hedskog L, et al. Dimebon(latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J Alzheimers Dis. 2010;21(2):389-402.