Acriflavine
产品说明书
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同义名 : | 吖啶黄 ;Acriflavinium chloride 3,6-Acridinediamine mix |
| CAS号 : | 8048-52-0 | |
| 货号 : | A1475625 | |
| 分子式 : | C27H25ClN6 | |
| 纯度 : | Cl,13.3-15.8% | |
| 分子量 : | 468.98 | |
| MDL号 : | MFCD00064307 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Acriflavine is recognized as a strong inhibitor of MCT4, effectively preventing the interaction between Basigin and MCT4. It notably reduces the proliferation and self-renewal capabilities of various glioblastoma neurosphere lines. Additionally, treatment with Acriflavine leads to a significant reduction in the intratumoral levels of VEGF and vascular development within tumors[1]. Acriflavine, also acting as a HIF-1 inhibitor, diminishes the viability and proliferation of CML cells by targeting their stem cell-like properties. Moreover, in a mouse model of CML, acriflavine is effective in curtailing leukemia progression and diminishing the sustenance of leukemia stem cells (LSC)[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.66mL 2.13mL 1.07mL |
21.32mL 4.26mL 2.13mL |
