LY367385 HCl
产品说明书
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同义名 : | LY367385 hydrochloride |
| CAS号 : | 2829282-00-8 | |
| 货号 : | A1475061 | |
| 分子式 : | C10H12ClNO4 | |
| 纯度 : | 95% | |
| 分子量 : | 245.66 | |
| MDL号 : | MFCD17215678 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | LY367385 HCl is a highly selective and potent mGluR1a antagonist. The IC50 for inhibition of quisqualate-induced hydrolysis of phosphatidylinositol (PI) by LY367385 HCl was 8.8 μM, whereas that for inhibition of mGlu5a was greater than 100 μM. LY367385 HCl is known to show neuroprotective, anticonvulsant, and anti-epileptic effects[1][2].During the toxic pulse period, LY367385 HCl combined with NMDA can reduce neuronal degeneration in a concentration-dependent manner, with the maximum reduction in NMDA toxicity ranging from 40% to 60%. LY367385 is more potent than LY367366, and neither compound by itself affects neuronal viability. LY367385 HCl exhibits potent neuroprotective effects, reducing the synergistic effect of (S)-3,5-Dihydroxyphenylglycine (DHPG) by 50% at a concentration of 10 nM. Under experimental conditions with higher concentrations of antagonists, LY367385 HCl can completely antagonize the amplifying effect of DHPG on NMDA toxicity [2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.07mL 0.81mL 0.41mL |
20.35mL 4.07mL 2.04mL |
40.71mL 8.14mL 4.07mL |
