ON1231320
产品说明书
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同义名 : | - |
| CAS号 : | 1312471-39-8 | |
| 货号 : | A1474056 | |
| 分子式 : | C22H15F2N5O3S | |
| 纯度 : | 99% | |
| 分子量 : | 467.45 | |
| MDL号 : | MFCD28502102 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ON1231320, a selective inhibitor of PLK2, exhibits an IC50 of 0.31 µM. It impedes the progression of the tumor cell cycle at the G2/M phase during mitosis, leading to apoptosis. As an arylsulfonyl pyrido-pyrimidinone compound, ON1231320 possesses antitumor properties[1][2]. ON1231320 effectively curbs the proliferation of a spectrum of 16 tumor cell lines, including DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, and GRANTA-519, with IC50 values ranging from 0.035 to 0.2 µM. Additionally, ON1231320 is not known to significantly affect tubulin polymerization[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.14mL 0.43mL 0.21mL |
10.70mL 2.14mL 1.07mL |
21.39mL 4.28mL 2.14mL |
