MF-766
产品说明书
 |
同义名 : | Compound 9a |
| CAS号 : | 1050656-06-8 | |
| 货号 : | A1471584 | |
| 分子式 : | C27H21F3N2O3 | |
| 纯度 : | 99% | |
| 分子量 : | 478.46 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MF-766 is a potent, selective, and orally active EP4 antagonist with a Ki value of 0.23 nM. In functional testing, MF-766 is a full antagonist with an IC50 value of 1.4 nM[1][2].Cells were pretreated with MF-766 for 1 hour at a concentration of less than 10 μM and then stimulated with IL-2 (50 ng/mL). After 18 hours of action, MF-766 reversed PGE2-inhibited IFN-γ secretion in human NK cells. In addition, the viability of NK cells was not affected by MF-766[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.45mL 2.09mL 1.05mL |
20.90mL 4.18mL 2.09mL |
