Zanzalintinib

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Chemical Structure| 2367004-54-2 同义名 : XL092; JUN04542
CAS号 : 2367004-54-2
货号 : A1463355
分子式 : C29H25FN4O5
纯度 : 99%+
分子量 : 528.53
MDL号 : MFCD34179545
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Zanzalintinib (XL092) is an orally active ATP-competitive inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as MET, VEGFR2, AXL, and MER, with respective IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays. It demonstrates anti-tumor activity and holds promise for kinase-dependent diseases and conditions research [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.46mL

1.89mL

0.95mL

18.92mL

3.78mL

1.89mL
参考文献

[1]J. Hsu, et al. XL092, a multi-targeted inhibitor of MET, VEGFR2, AXL and MER with an optimized pharmacokinetic profile. European Journal of Cancer, Volume 138, Supplement 2, October 2020, Page S16.

[2]Lynne Canne Bannen, et al. Compounds for the treatment of kinase-dependent disorders. WO2019148044A1.