Fisetin
产品说明书
 |
同义名 : | 非瑟酮 ;CI-75620; NSC 656275; CCRIS 9034; Fisetholz; NSC 407010 |
| CAS号 : | 528-48-3 | |
| 货号 : | A145931 | |
| 分子式 : | C15H10O6 | |
| 纯度 : | 95% | |
| 分子量 : | 286.24 | |
| MDL号 : | MFCD00006829 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fisetin is a natural flavonoid, found in various fruits and vegetables, and it is reported to have neurotrophic, anticarcinogenic, anti-inflammatory, and other health beneficial effects[3]. Recent studies revealed its antitumor effects in various cancer model. Fisentin (0,100, 200, and 400μM) reduced PANC-1 cell viability in a dose- and time-dependent manner, and also inhibited the proliferation of PANC-1 cells. In a nude mouse xenograft model, tumor sizes were significantly reduced in fisetin-treated mice (300mg/kg body weight, i.p., every other day)[4]. HepG2 cells that were exposed to different concentrations of fisetin (25, 50, and 100μM) for 24 h showed decreased autophagic flux formation in a dose-dependent manner. The suppression of autophagy by fisetin may serve as an effective therapeutic strategy against HCC[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.49mL 0.70mL 0.35mL |
17.47mL 3.49mL 1.75mL |
34.94mL 6.99mL 3.49mL |
| 参考文献 |
|---|