Indophagolin
产品说明书
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同义名 : | - |
| CAS号 : | 1207660-00-1 | |
| 货号 : | A1453039 | |
| 分子式 : | C19H15BrClF3N2O3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 523.75 | |
| MDL号 : | MFCD14721653 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Indophagolin is a potent autophagy inhibitor containing indoline (IC50=140 nM). It antagonizes the purinergic receptors P2X4, P2X1, and P2X3 with IC50 values of 2.71, 2.40, and 3.49 μM, respectively. Additionally, Indophagolin antagonizes Gq-protein-coupled receptors P2Y4, P2Y6, and P2Y11 (IC50s =3.4~15.4 μM). It exhibits a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.91mL 0.38mL 0.19mL |
9.55mL 1.91mL 0.95mL |
19.09mL 3.82mL 1.91mL |
| 参考文献 |
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