N,N-Diethyl-m-toluamide (DEET)
产品说明书
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同义名 : | N,N-二乙基间甲苯甲酰胺 ;Diethyltoluamide; DEET; NSC 33840; N,N-Diethyl-m-toluamide |
| CAS号 : | 134-62-3 | |
| 货号 : | A143062 | |
| 分子式 : | C12H17NO | |
| 纯度 : | 98% | |
| 分子量 : | 191.27 | |
| MDL号 : | MFCD00009046 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | DEET, the insect repellent (N,N-diethyl-3-methylbenzamide), is a multimodal compound that acts as a spatial repellent as well as an irritant (contact repellent). When blood was mixed either with 0.1 or 1% DEET, female southern house mosquitoes spent significantly less time feeding than the time spent feeding on blood mixed only with the solvent. DEET, permethrin, and, to a lesser extent, picaridin, act as feeding deterrents[3]. DEET inhibits food ingestion by Drosophila melanogaster flies, and this repellency is mediated by bitter taste neurons in the proboscis. DEET contact chemorepellency is mediated exclusively by the tarsal segments of the legs and not the proboscis[4]. DEET induces favorable repellency against insects by acting on the sensory nervous system. DEET side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (AChE), muscarinic M1 and M3 receptor and the participation of the second messenger nitric oxide (NO)[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00938379 | Malaria Dengu... 展开 >>e Japanese Encephalitis 收起 << | Phase 3 | Unknown | June 2011 | Lao People's Democratic Republ... 展开 >>ic Rural villages in Attepu and Sekong Provinces, Laos PDR Recruiting Pakse, Attepu, Lao People's Democratic Republic Contact: Vanessa Chen-Hussey, MSc 856 (0)21 353 408 ext 116 vanessa.chen-hussey@lshtm.ac.uk Principal Investigator: Vanessa Chen-Hussey, MSc 收起 << |
| NCT02938975 | Malaria | Phase 3 | Not yet recruiting | June 2019 | Tanzania ... 展开 >> Ifakara Health Institute Not yet recruiting Bagamoyo, Tanzania, 74 Contact: Mercy Nyika +255788-720602 mnyika@ihi.or.tz Principal Investigator: Sarah J Moore, PhD Sub-Investigator: Daniel F Msellemu, MSc 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.23mL 1.05mL 0.52mL |
26.14mL 5.23mL 2.61mL |
52.28mL 10.46mL 5.23mL |
| 参考文献 |
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