同义名 :	Rhabarberone; 3-Hydroxymethylchrysazine; NSC 38628
	CAS号 :	481-72-1
	货号 :	A142364
	分子式 :	C15H10O5
	纯度 :	97%
	分子量 :	270.24
	MDL号 :	-
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor properties, capable of binding to and inhibiting the kinase activity of mTORC2, thus exerting antiproliferative effects and inducing apoptosis in cells[1]. It also shows antiviral efficacy against the influenza A virus[2].

细胞研究
细胞系	浓度	检测类型	检测时间	活性说明	数据源
A2780 cells		Cytotoxicity assay		Cytotoxicity against human A2780 cells, IC50=26 μM	24326280
HCT116 cells		Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM	17949858
HepG2 cells		Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM	17949858

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.70mL 0.74mL 0.37mL	18.50mL 3.70mL 1.85mL	37.00mL 7.40mL 3.70mL

参考文献
[1]Ho SL, Poon CY, et al. Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity. Curr Alzheimer Res. 2015;12(5):424-33. [2]Heidemann A, Volkner W, Mengs U. Genotoxicity of aloeemodin in vitro and in vivo. Mutat Res. 1996 Mar 1;367(3):123-33.