Naratriptan HCl
产品说明书
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同义名 : | 盐酸那拉曲坦 ;GR-85548A hydrochloride; Naratriptan (hydrochloride); Naratriptan hydrochloride |
| CAS号 : | 143388-64-1 | |
| 货号 : | A140046 | |
| 分子式 : | C17H26ClN3O2S | |
| 纯度 : | 98% | |
| 分子量 : | 371.93 | |
| MDL号 : | MFCD08141821 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Naratriptan Hydrochloride is a 5-HT1 receptor agonist, which can act on migraine. Naratriptan has high affinity for human recombinant 5HT1B and 5HT1D receptors (pKi = 8.7 +/- 0.03 and 8.3 +/- 0.1, respectively) and causes contractions of dog isolated basilar and middle cerebral artery (EC50 values of 0.11 and 0.07 microM, respectively)[3]. Naratriptan 2.5–10 mg was superior to placebo for acute migraine treatment in all 6 RCTs(randomised, controlled trials ) in adults, short-term prophylaxis with naratriptan 1 mg b.i.d was superior to placebo for menstruation-associated migraine (MAM)[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01332500 | - | Completed | - | - | |
| NCT01435941 | - | Completed | - | - | |
| NCT01332500 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.69mL 0.54mL 0.27mL |
13.44mL 2.69mL 1.34mL |
26.89mL 5.38mL 2.69mL |
| 参考文献 |
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