CMC2.24

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Chemical Structure| 1255639-43-0 同义名 : TRB-N0224
CAS号 : 1255639-43-0
货号 : A1399239
分子式 : C26H21NO5
纯度 : 99%+
分子量 : 427.45
MDL号 : -
存储条件:

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 CMC2.24 is an orally active tricarbonylmethane agent that is effective against pancreatic tumours in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs, with IC50 values ranging from 2-69 μM. CMC2.24 restores chondrogenic homeostasis via the NF-κB/HIF-2α axis and CMC2.24 can restore cartilage homeostasis through the NF-κB/HIF-2α axis and inhibit chondrocyte apoptosis, thereby alleviating the progression of osteoarthritis[1][2][3].CMC2.24 reduces p-STAT3-Ser727 levels and induces mitochondrial reactive oxygen species and mitochondrial cell death in pancreatic cancer cells. CMC2.24 induces mitochondrial reactive oxygen species and intrinsic cell apoptosis. CMC2.24 inhibits the growth of pancreatic cancer in vitro at concentrations of 0-60 μM for 24 hours[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.34mL

0.47mL

0.23mL

11.70mL

2.34mL

1.17mL

23.39mL

4.68mL

2.34mL