同义名 :	氯二甲酚;对氯间二甲酚;4-氯-3,5-二甲基苯酚;酚洁新PX ;p-chloro-m-xylenol; Chloroxylenol; HSDB7427
	CAS号 :	88-04-0
	货号 :	A139376
	分子式 :	C8H9ClO
	纯度 :	98%
	分子量 :	156.61
	MDL号 :	MFCD00002324
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Chloroxylenol is an antimicrobial ingredient that is frequently used in antiseptics/disinfectants for skin (e.g. hand soap) and non-living surfaces[3]. Triclosan and chloroxylenol decrease the degree of fluidity of membranes and this effect is more pronounced in bacterial membranes[4]. The toxicological data for chloroxylenol indicate lack of genotoxicity, no evidence of carcinogenicity, and minimal systemic toxicity[5]. Treatment of S. aureus with the antiseptic chloroxylenol alone did not decrease biofilm cell viability; however, the combination of chloroxylenol and P. aeruginosa supernatant led to a 4-log reduction in S. aureus biofilm viability compared to exposure to chloroxylenol alone[6].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02139033	Keratoconjunctivitis Sicca	Phase 4	Completed	-	United States, Massachusetts ... 展开 >> Andover, Massachusetts, United States, 01810 收起 <<
NCT01521507	Meibomian Gland Dysfunction ... 展开 >> Dry Eye 收起 <<	Not Applicable	Completed	-	United States, Arkansas ... 展开 >> McDonald Eye Associates Fayetteville, Arkansas, United States, 72703 United States, California Harvard Eye Associates Laguna Hills, California, United States, 92653 United States, Florida Center for Excellence in Eye Care Miami, Florida, United States, 33176 United States, Illinois Chicago Cornea Consultants, Ltd. Hoffman Estates, Illinois, United States, 60169 Jackson Eye Lake Villa, Illinois, United States, 50046 United States, Kentucky Cincinnati Eye Institute - Northern Kentucky Edgewood, Kentucky, United States, 41017 United States, Massachusetts Charles River Eye Associates Winchester, Massachusetts, United States, 01890 United States, Minnesota Associated Eye Care Stillwater, Minnesota, United States, 55082 United States, Missouri Ophthalmology Consultants, Ltd. St. Louis, Missouri, United States, 63131 收起 <<
NCT01521507	-		Completed	-	-

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	6.39mL 1.28mL 0.64mL	31.93mL 6.39mL 3.19mL	63.85mL 12.77mL 6.39mL

参考文献

[1]Gatti R, Roveri P, et al. HPLC-fluorescence determination of chlorocresol and chloroxylenol in pharmaceuticals. J Pharm Biomed Anal. 1997 Nov;16(3):405-12. [2]Aly R, Maibach HI. Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes. Am J Infect Control. 1988 Aug;16(4):173-7. [3]Choi D, Oh S. Removal of Chloroxylenol Disinfectant by an Activated Sludge Microbial Community. Microbes Environ. 2019;34(2):129–135 [4]Poger D, Mark AE. Effect of Triclosan and Chloroxylenol on Bacterial Membranes. J Phys Chem B. 2019;123(25):5291–5301 [5]Yost LJ, Rodricks JD, Turnbull D, et al. Human health risk assessment of chloroxylenol in liquid hand soap and dishwashing soap used by consumers and health-care professionals. Regul Toxicol Pharmacol. 2016;80:116–124 [6]Orazi G, Ruoff KL, O'Toole GA. Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics. mBio. 2019;10(4):e01501-19.